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ea0099p261 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Familial partial lipodystrophy:genetic and clinical data from a greek referral center

Kountouri Aikaterini , Korakas Emmanouil , Maratou Eirini , Ikonomidis Ignatios , Balampanis Konstantinos , Pliouta Loukia , Liatis Stavros , Tentolouris Nikolaos , Toulas Panagiotis , Kousathana Foteini , Giatzakis Christoforos , Dimitriadis George , Lambadiari Vaia

Background: Familial partial lipodystrophy (FPLD) is a rare syndrome in which a patients phenotype is not dependent merely on the specific genetic mutation, but also on a combination of other demographic, environmental and genetic factors. In this report, we present a large cohort of novel mutation in FPLD patients from a large referral center in Greece and we investigate the possible relationship between the genetic variations detected and their phenotype and the effect...

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ea0099p464 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Combined dulaglutide-dapagliflozin treatment improves vascular dysfunction and albuminuria vs DPP4 inhibitors independently of glycaemic control

Korakas Emmanouil , Ikonomidis Ignatios , Thymis John , Kountouri Aikaterini , Pliouta Loukia , Katogiannis Konstantinos , Benas Dimitris , Balampanis Konstantinos , Prentza Vasiliki , Kousathana Foteini , Kostelli Gavriela , Dimitriadis George , Raptis Athanasios , Lambadiari Vaia

Background: The association between diabetes mellitus and diabetic nephropathy with vascular and endothelial properties is well-established. In this study, we compared the effect of combined treatment with dulaglutide and dapagliflozin versus DPP-4 inhibitors on endothelial glycocalyx, arterial stiffness, myocardial function and albuminuria in patients with type 2 diabetes mellitus and albuminuria.Methods: A total of 60 patients with type 2 diabetes mell...

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Endocrine Abstracts

Familial partial lipodystrophy:genetic and clinical data from a greek referral center

Combined dulaglutide-dapagliflozin treatment improves vascular dysfunction and albuminuria vs DPP4 inhibitors independently of glycaemic control

BiosciAbstracts